Sirt1 regulates acrosome biogenesis by modulating autophagic flux during spermiogenesis in mice
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چکیده
منابع مشابه
Sirt1 regulates acrosome biogenesis by modulating autophagic flux during spermiogenesis in mice.
Sirt1 is a member of the sirtuin family of proteins and has important roles in numerous biological processes. Sirt1-/- mice display an increased frequency of abnormal spermatozoa, but the mechanism of Sirt1 in spermiogenesis remains largely unknown. Here, we report that Sirt1 might be directly involved in spermiogenesis in germ cells but not in steroidogenic cells. Germ cell-specific Sirt1 knoc...
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ژورنال
عنوان ژورنال: Development
سال: 2016
ISSN: 1477-9129,0950-1991
DOI: 10.1242/dev.147074